Prof.Dr. Skorn Mongkolsuk Faculty of Science, Mahidol University and Chulabhorn Research Institute The Pseudomonas aeruginosa PAO1 thiol peroxidase homolog (Tpx) belongs to a family of enzymes implicated in the removal of toxic peroxides. We have shown the expression of tpx to be highly inducible with redox cycling/superoxide generators and diamide and weakly inducible with organic… (read more)

Assist.Prof. Sunhapas Soodvilai Faculty of Science, Mahidol University Cancer is highly prevalent in Thailand whereas chemotherapeutic treatment is at ineffective. In addition, the serious side effects litmit the use; therefore, new molecular targets for treatment of cancer is required to increase the effecicay. Our present data demonstrated the tagets of treatment to improve effective treatment… (read more)

Dr. Suvit Loprasert Chulabhorn Graduate Institute and Chulabhorn Research Institute Phthalate esters are a class of endocrine disrupting compounds that are widely used in various industries, and are suspected carcinogens. The two esterase enzymes named esterase B and G were successfully isolated from soil bacterium Sphingobium sp. SM42. These enzymes are responsible for degradation of… (read more)

Dr. Paiboon Vattanaviboon Chulabhorn Graduate Institute and Chulabhorn Research Institute The role of the nfuA gene encoding an iron-sulfur (Fe-S) cluster scaffold protein in the human pathogen, Pseudomonas aeruginosa, was investigated. The expression of nfuA was induced upon exposure to herbicide paraquat and other superoxide generators and thiol-depleting agent and was mediated by IscR, an… (read more)

Dr. Mayuree Fuangthong Chulabhorn Graduate Institute and Chulabhorn Research Institute Pseudomonas aeruginosa an opportunistic pathogen of humans that causes nosocomial infections in hospitalized patients, immunocompromised hosts and patients with burns as well as infecting those with cystic fibrosis. Among many virulence factors, its ability to survive oxidative stress is one of the important characteristics allowing… (read more)