Center of Excellence on Environmental Health and Toxicology (EHT)
| Cytoskeletal proteins, especially microtubules and actin filaments are important structures required for cancer cell proliferation and migration. Molecules or compounds that disrupt their functions could interfere with proliferation and migration of the cancer cells, and therefore serve as great candidates for developing novel compounds for cancer treatment. Compounds found in Krai-Hangnak (Phyllanthus taxodiifolius) have been shown to kill several types of cancer cells, but the effect of Krai-Hangnak extract on brain cancer cells has never been determined. In addition, its mechanisms of action are still unclear. Here we show that Krai-Hangnak delays proliferation and migration of brain cancer cells. We also show that Krai-Hangnak disrupts microtubule polymerization and actin filament organization in brain cancer cells.
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