Interference of Arsenic on Signaling Crosstalk between Proinflammatory Cytokines and EGFR in Cancer Cells
Dr. Pattama Singhirunnusorn Chulabhorn Research Institute Sodium arsenite (As) affects many cellular responses such as apoptosis, cell proliferation, differentiation, angiogenesis and increased risk of cancer. We hypothesis that sodium arsenite interfere proinflammatory cytokine factor (TNF-alpha-induced apoptosis process via EGFR and MAPK activation. Epidermal growth factor receptor (EGFR) pathway is mainly growth factor protein that had… (read more)