Archive for July 2014

The Effects of Herbicide on Antibiotic Resistance Profile in Stenotrophomonas maltophilia, an Emerging Cause of Nosocomial Infections

Assoc. Prof. Dr. Paiboon Vattanaviboon Chulabhorn Research Institute Stenotrophomonas maltophilia MfsA (Smlt1083) is a multidrug efflux pump in the major facilitator superfamily (MFS). Deletion of mfsA renders the strain more susceptible to multiple structurally non-related drugs including paraquat, kanamycin, streptomycin, neomycin, norfloxacin, chloramphenicol and tetracycline. No alteration in the susceptibility levels of the delta-mfsA mutant… (read more)

Effects of Elevated Temperature Related to Heat/Oxidative Stress in Human Pathogen; Pseudomonas aeruginosa

Prof.Dr. Skorn Mongkolsuk Faculty of Science, Mahidol University and Chulabhorn Research Institute The Pseudomonas aeruginosa PAO1 thiol peroxidase homolog (Tpx) belongs to a family of enzymes implicated in the removal of toxic peroxides. We have shown the expression of tpx to be highly inducible with redox cycling/superoxide generators and diamide and weakly inducible with organic… (read more)