Archive for August 2012

Development of potent in vitro model for determination of cellular toxicity and cellular detoxification using yeast Saccharomyces cerevisiae

Asst. Prof. Dr. Krongchan Ratapradit Faculty of Science, Burapha University This research work aimed to optimize in vitro cytotoxic assay using yeast as biological model. In particular, factors affecting yeast based cytotoxic assay and sensitivity of yeast after exposure to toxic substance have been investigated. Initially, four yeast strains have been evaluated and finally two… (read more)

Mechanisms of arsenic-induced cell proliferation: Involvement of vascular endothelial factor (VEGF) and epidermal growth factor receptor (EGFR)

Assoc. Prof. Dr. Piyajit Watcharasit Chulabhorn Research Institute Arsenic is widely contaminated in environment. Epidemiological studies demonstrated that chronic exposure of arsenic leads to cancers in multiple organs including skin, lungs, and bladder. However, underlined mechanisms of arsenic carcinogenesis remain elusive. Arsenic has been shown to cause increase in cell proliferation which can potentially initiate… (read more)